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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| BALSALAZIDE (has an active metabolite)
| BALSALAZIDE | METABOLISM | ORAL | Cmax 1.42 MICROMOLAR (3 TIMES 750 MILLIGRAM) Tmax 0.8 HOUR PPB 99 PERCENT HT 1.9 HOUR (SINGLE DOSE) SOLUBILITY FREELY SOLUBLE IN WATER | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 BACTERIAL NADPH AZOREDUCTASE | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MESALAMINE (is an active metabolite)
| MESALAMINE | METABOLISM | RECTAL ORAL | Cmax 17.6 MICROMOLAR Tmax 6 HOUR F 28 PERCENT VD 21.4 LITER (65 KILOGRAM) PPB 43 PERCENT Cl 36.2 LITER / HOUR (65 KILOGRAM) HT 1 HOUR | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 -- Prostaglandin G,H synthase 1 UNIPROT P23219 PTGS1 more at DrugCentral | EMA | |||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OLSALAZINE (has an active metabolite)
| OLSALAZINE | METABOLISM | ORAL | Cmax 6.2 MICROMOLAR Tmax 1 HOUR F 2.4 PERCENT VD 4.5 LITER (65 KILOGRAM) PPB 99 PERCENT Cl 4.6 LITER / HOUR (65 KILOGRAM) HT 0.9 HOUR SOLUBILITY SOLUBLE IN WATER | Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 -- Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG more at DrugCentral | EMA | ||||
| 4 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SULFASALAZINE (has an active metabolite)
| SULFASALAZINE | METABOLISM | ORAL | Cmax 15 MICROMOLAR Tmax 6 HOUR F 15 PERCENT VD 7.5 LITER PPB 99.3 PERCENT Cl 1 LITER / HOUR HT 7.6 HOUR | Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5 -- Cyclooxygenase UNIPROT P23219 PTGS1 more at DrugCentral | EMA | ||||
