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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ETOPOSIDE PHOSPHATE (has an active metabolite)

ETOPOSIDE PHOSPHATE


ATC L01CB01

ANTINEOPLASTIC
NUCLEIC ACID SYNTHESIS INHIBITORS
INDUCTION OF DNA STRAND BREAKS BY AN INTERACTION WITH DNA-TOPOISOMERASE II OR THE FORMATION OF FREE RADICALS

INJECTION

SOLUBILITY WATER SOLUBLE ESTER OF ETOPOSIDE

DNA TOPOISOMERASE 2

DNA TOPOISOMERASE II ALPHA INHIBITOR CHEMBL1806 DNA TOPOISOMERASE II ALPHA P11388 DNA TOPOISOMERASE 2-ALPHA HOMO SAPIENS ENZYME ISOMERASEANSM (in French)

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