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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GLYBURIDE

GLYBURIDE


ATC A10BB01

METABOLISM
ANTIDIABETIC
BLOOD-GLUCOSE-LOWERING DRUG BY STIMULATING THE RELEASE OF INSULIN FROM THE PANCREAS
SULFONYLUREA HYPOGLYCEMIC DRUGS

ORAL

VD 5.2 LITER (65 KILOGRAM)

PPB 97.9 PERCENT

Cl 3.2 LITER / HOUR (65 KILOGRAM)

HT 10 HOUR

SOLUBILITY AQUEOUS SOLUBILITY INCREASES WITH PH AS A RESULT OF SALT FORMATION

ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL

PDB 5IFU (CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRORS, PROLINE--TRNA LIGASE) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH GLYBURIDE)

LIGAND CODE = GBM (link to the list of PDB complexes)

Download experimental 3D coordinates of GBM with added hydrogens

SULFONYLUREA RECEPTOR 1, Q09428 ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 8 HOMO SAPIENS TRANSPORTER NTPASE ATP BINDING CASSETTE MRPANSM (in French)

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