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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GLYBURIDE

GLYBURIDE


ATC A10BB01

METABOLISM
ANTIDIABETIC
BLOOD-GLUCOSE-LOWERING DRUG BY STIMULATING THE RELEASE OF INSULIN FROM THE PANCREAS
SULFONYLUREA HYPOGLYCEMIC DRUGS

ORAL

VD 5.2 LITER (65 KILOGRAM)

PPB 97.9 PERCENT

Cl 3.2 LITER / HOUR (65 KILOGRAM)

HT 10 HOUR

SOLUBILITY AQUEOUS SOLUBILITY INCREASES WITH PH AS A RESULT OF SALT FORMATION

ATP-SENSITIVE POTASSIUM CHANNEL OF THE PANCREATIC B-CELL

PDB 5IFU (CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRORS, PROLINE--TRNA LIGASE) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH GLYBURIDE)

LIGAND CODE = GBM (link to the list of PDB complexes)

Download experimental 3D coordinates of GBM with added hydrogens

Sulfonylurea receptor 1, Kir6.2 UNIPROT Q09428 ABCC8

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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