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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ACETAZOLAMIDE
| ACETAZOLAMIDE | SENSORY | ORAL INJECTION | Tmax 4.5 HOUR F 100 PERCENT VD 13 LITER (65 KILOGRAM) PPB 93 PERCENT Cl 1.1 LITER / HOUR (65 KILOGRAM) HT 3.5 HOUR (PMID9650543) SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | CARBONIC ANHYDRASE PDB 1AZM (DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I) LIGAND CODE = AZM (link to the list of PDB complexes) Download experimental 3D coordinates of AZM with added hydrogens | Carbonic anhydrase 2 UNIPROT P00918 CA2 -- Carbonic anhydrase 1 UNIPROT P00915 CA1 more at DrugCentral | EMA | |||
