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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COLISTIMETHATE (has an active metabolite)
| COLISTIMETHATE | ANTIINFECTIVES | INJECTION | VD 49.4 LITER (EQN) Cl 13.7 LITER / HOUR (PMID19433570) HT 2.5 HOUR | MEMBRANE | CELL MEMBRANE INHIBITOR CHEMBL2364031 CELL MEMBRANE BACTERIA | ANSM (in French) | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COLISTIN (is an active metabolite)
| COLISTIN | ANTIINFECTIVES | ORAL OTIC | Cmax 1.99 MICROMOLAR (PMID19433570) VD 189 LITER (PMID19433570) Cl 13.7 LITER / HOUR (PMID19433570) HT 14.4 HOUR (PMID19433570) | MEMBRANE | CELL OUTER MEMBRANE INHIBITOR CHEMBL2364032 CELL OUTER MEMBRANE BACTERIA | ANSM (in French) | |||
