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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NILOTINIB
| NILOTINIB | ANTINEOPLASTIC | ORAL | Tmax 3 HOUR PPB 98 PERCENT HT 17 HOUR SOLUBILITY IN AQUEOUS SOLUTIONS DECREASES WITH INCREASING PH | BCR-ABL TYROSINE KINASE PDB 3CS9 (HUMAN ABL KINASE IN COMPLEX WITH NILOTINIB) LIGAND CODE = NIL (link to the list of PDB complexes) Download experimental 3D coordinates of NIL with added hydrogens | Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 more at DrugCentral | EMA | |||
