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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LAPATINIB

LAPATINIB


ATC L01XE07

ANTINEOPLASTIC AGENTS
PROTEIN KINASE INHIBITORS
METASTATIC BREAST CANCER WHOSE TUMORS OVEREXPRESS HER2

ORAL

Cmax 4.18 MICROMOLAR (1.250 MILLIGRAM DAILY))

Tmax 4 HOUR

PPB 99 PERCENT

HT 14.2 HOUR

SOLUBILITY 0.007 MILLIGRAM / MILLILITER

HUMAN EPIDERMAL RECEPTOR TYPE 2 (RECEPTOR TYROSINE-PROTEIN KINASE HER2 ERBB-2 KI = 3 NANOMOLAR)
EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR KI = 13 NANOMOLAR)

PDB 1XKK (EGFR KINASE DOMAIN COMPLEXED WITH A QUINAZOLINE INHIBITOR- GW572016)

LIGAND CODE = FMM (link to the list of PDB complexes)

Download experimental 3D coordinates of FMM with added hydrogens

EPIDERMAL GROWTH FACTOR RECEPTOR ERBB1 INHIBITOR CHEMBL203 EPIDERMAL GROWTH FACTOR RECEPTOR ERBB1 P00533 EPIDERMAL GROWTH FACTOR RECEPTOR HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK EGFRANSM (in French)

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