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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SITAGLIPTIN

SITAGLIPTIN


ATC A10BH01
ATC A10BH51
ATC A10BD24
ATC A10BD07
ATC A10BD12

METABOLISM
DPP-4 INHIBITORS
HYPOGLYCEMIC AGENTS BY SLOWING THE INACTIVATION OF INCRETIN HORMONES
ANTI-DIABETIC

ORAL

Cmax 950 NANOMOLAR (100 MILLIGRAM)

F 87 PERCENT

VD 198 LITER

PPB 38 PERCENT

Cl 11 LITER / HOUR (EQN)

HT 12.4 HOUR

SOLUBILITY SOLUBLE IN WATER

DIPEPTIDYL PEPTIDASE 4 (DPP-4)

PDB 4FFW (CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPP4, DPP-IV, CD26) IN COMPLEX WITH FAB + SITAGLIPTIN)

LIGAND CODE = 715 (link to the list of PDB complexes)

Download experimental 3D coordinates of 715 with added hydrogens

DIPEPTIDYL PEPTIDASE IV INHIBITOR CHEMBL284 DIPEPTIDYL PEPTIDASE IV P27487 DIPEPTIDYL PEPTIDASE 4 HOMO SAPIENS ENZYME PROTEASE SERINE SC S9BANSM (in French)

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