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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ALISKIREN

ALISKIREN


ATC C09XA02
ATC C09XA53
ATC C09XA52
ATC C09XA54
ATC C09DX02

CARDIOVASCULAR
ANTIHYPERTENSIVE
LOWER BLOOD PRESSURE
RENIN INHIBITOR

ORAL

Tmax 2 HOUR

F 2.5 PERCENT

VD 135 LITER

PPB 49 PERCENT

Cl 9 LITER / HOUR

HT 24 HOUR

SOLUBILITY HIGHLY SOLUBLE IN WATER

RENIN

PDB 2V0Z (CRYSTAL STRUCTURE OF RENIN WITH INHIBITOR 10 (ALISKIREN))

LIGAND CODE = C41 (link to the list of PDB complexes)

Download experimental 3D coordinates of C41 with added hydrogens

RENIN INHIBITOR CHEMBL286 RENIN P00797 RENIN HOMO SAPIENS ENZYME PROTEASE ASPARTIC AA A1AANSM (in French)

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