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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DARUNAVIR

DARUNAVIR


ATC J05AE10
ATC J05AR14
ATC J05AR22
ATC J05AR26

ANTIINFECTIVES
ANTIVIRAL AGENTS
HIV PROTEASE INHIBITOR

ORAL

F 59 PERCENT

VD 417 LITER (EQN)

PPB 95 PERCENT

Cl 19.3 LITER / HOUR

HT 15 HOUR

SOLUBILITY 0.15 MILLIGRAM / MILLILITER IN WATER

HIV-1 PROTEASE

PDB 4Q1W (MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE)

LIGAND CODE = 017 (link to the list of PDB complexes)

Download experimental 3D coordinates of 017 with added hydrogens

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE INHIBITOR CHEMBL243 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE Q72874 POL POLYPROTEIN HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME PROTEASE ASPARTIC AA A2AANSM (in French)

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