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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SUNITINIB

SUNITINIB


ATC L01XE04

ANGIOGENESIS INHIBITORS
ANTINEOPLASTIC AGENTS
KINASE INHIBITOR
TREATMENT OF GASTROINTESTINAL STROMAL TUMOR (GIST), GASTROINTESTINAL STROMAL TUMOR (GIST) AND PANCREATIC NEUROENDOCRINE TUMORS
INHIBITED THE PHOSPHORYLATION OF MULTIPLE RTKS (MULTIPLE RECEPTOR TYROSINE KINASES)

ORAL

Cmax 0.2055 MICROMOLAR

VD 2230 LITER

PPB 95 PERCENT

Cl 48 LITER / HOUR

HT 50 HOUR

SOLUBILITY 25 MILLIGRAM / MILLILITER

OF PLATELET-DERIVED GROWTH FACTOR RECEPTORS (PDGFRALPHA AND PDGFRBETA)
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS (VEGFR1, VEGFR2 AND VEGFR3)
STEM CELL FACTOR RECEPTOR (KIT)
FMS-LIKE TYROSINE KINASE-3 (FLT3)
COLONY STIMULATING FACTOR RECEPTOR TYPE 1 (CSF-1R)
GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR (RET)

PDB 2Y7J (STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2)

LIGAND CODE = B49 (link to the list of PDB complexes)

Download experimental 3D coordinates of B49 with added hydrogens

MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR INHIBITOR CHEMBL1844 MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR P07333 MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK PDGFRANSM (in French)

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