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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SUNITINIB
| SUNITINIB | ANTINEOPLASTIC | ORAL | Cmax 0.2055 MICROMOLAR VD 2230 LITER PPB 95 PERCENT Cl 48 LITER / HOUR HT 50 HOUR SOLUBILITY 25 MILLIGRAM / MILLILITER | OF PLATELET-DERIVED GROWTH FACTOR RECEPTORS (PDGFRALPHA AND PDGFRBETA) VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS (VEGFR1, VEGFR2 AND VEGFR3) STEM CELL FACTOR RECEPTOR (KIT) FMS-LIKE TYROSINE KINASE-3 (FLT3) COLONY STIMULATING FACTOR RECEPTOR TYPE 1 (CSF-1R) GLIAL CELL-LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR (RET) PDB 2Y7J (STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2) LIGAND CODE = B49 (link to the list of PDB complexes) Download experimental 3D coordinates of B49 with added hydrogens | Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT more at DrugCentral | EMA | |||
