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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SORAFENIB

SORAFENIB


ATC L01EX02

ANTINEOPLASTIC
PROTEIN KINASE INHIBITOR
TREATMENT OF HEPATOCELLULAR CARCINOMA AND RENAL CELL CARCINOMA
MULTIPLE INTRACELLULAR RECEPTOR TYROSINE KINASES
CELL SURFACE KINASES

ORAL

Tmax 3 HOUR

F 43.5 PERCENT

PPB 99.5 PERCENT

HT 36.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

CRAF
BRAF
MUTANT BRAF
KIT
FLT-3
RET
VEGFR-1
VEGFR-2
VEGFR-3
PDGFR-BETA

PDB 1UWJ (THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006.)

LIGAND CODE = BAX (link to the list of PDB complexes)

Download experimental 3D coordinates of BAX with added hydrogens

Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Mast,stem cell growth factor receptor Kit UNIPROT P10721 KIT

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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