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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SORAFENIB

SORAFENIB


ATC L01XE05

ANTICANCER AGENTS
ANTINEOPLASTIC AGENTS
PROTEIN KINASE INHIBITOR
TREATMENT OF HEPATOCELLULAR CARCINOMA AND RENAL CELL CARCINOMA
MULTIPLE INTRACELLULAR RECEPTOR TYROSINE KINASES
CELL SURFACE KINASES

ORAL

Tmax 3 HOUR

F 43.5 PERCENT

PPB 99.5 PERCENT

HT 36.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

CRAF
BRAF
MUTANT BRAF
KIT
FLT-3
RET
VEGFR-1
VEGFR-2
VEGFR-3
PDGFR-BETA

PDB 1UWJ (THE COMPLEX OF MUTANT V599E B-RAF AND BAY439006.)

LIGAND CODE = BAX (link to the list of PDB complexes)

Download experimental 3D coordinates of BAX with added hydrogens

SERINE/THREONINE-PROTEIN KINASE RAF INHIBITOR CHEMBL1906 SERINE/THREONINE-PROTEIN KINASE RAF P04049 RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TKL RAFANSM (in French)

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