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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RASAGILINE

RASAGILINE


ATC N04BD02

NERVOUS SYSTEM
COGNITION ENHANCER
ANTIPARKINSONIAN
MONOAMINE OXIDASE INHIBITORS
NEUROPROTECTIVE AGENTS

ORAL

F 36 PERCENT

VD 87 LITER

PPB 91 PERCENT

Cl 20 LITER / HOUR (EQN)

HT 3 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

MONOAMINE OXIDASE TYPE A (MAO-A)
MONOAMINE OXIDASE TYPE B (MAO-B)
APOPTOSIS REGULATOR BCL-2
AMINE OXIDASE [FLAVIN-CONTAINING] B

PDB 2C75 (FUNCTIONAL ROLE OF THE AROMATIC CAGE IN HUMAN MONOAMINE OXIDASE B: STRUCTURES AND CATALYTIC PROPERTIES OF TYR435 MUTANT PROTEINS)

LIGAND CODE = RSA (link to the list of PDB complexes)

Download experimental 3D coordinates of RSA with added hydrogens

MONOAMINE OXIDASE B INHIBITOR CHEMBL2039 MONOAMINE OXIDASE B P27338 AMINE OXIDASE [FLAVIN-CONTAINING] B HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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