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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ATAZANAVIR

ATAZANAVIR


ATC J05AE08
ATC J05AR15
ATC J05AR23

ANTIINFECTIVES
HIV PROTEASE INHIBITOR

ORAL

Cmax 8.7 MICROMOLAR

Tmax 2.5 HOUR

PPB 86 PERCENT

HT 7.9 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER 4 TO 5 MILLIGRAM / MILLILITER WITH THE PH=1.9 AT 24 DEGREE CELSIUS

HIV-1 PROTEASE

PDB 3EKW (CRYSTAL STRUCTURE OF THE INHIBITOR ATAZANAVIR (ATV) IN COMPLEX WITH A MULTI-DRUG RESISTANCE HIV-1 PROTEASE VARIANT (L10I/G48V/I54V/V64I/V82A) REFER: FLAP+ IN CITATION.)

LIGAND CODE = DR7 (link to the list of PDB complexes)

Download experimental 3D coordinates of DR7 with added hydrogens

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE INHIBITOR CHEMBL243 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE Q72874 POL POLYPROTEIN HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME PROTEASE ASPARTIC AA A2AANSM (in French)

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