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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PEMETREXED

PEMETREXED


ATC L01BA04

ANTIMETABOLITES
ANTINEOPLASTIC
FOLIC ACID INHIBITORS
TREATMENT OF NONSQUAMOUS NON-SMALL CELL LUNG CANCER AND MESOTHELIOMA
PEMETREXED IS CONVERTED TO POLYGLUTAMATE FORMS BY THE ENZYME FOLYLPOLYGLUTAMATE SYNTHETASE. POLYGLUTAMATE ARE INHIBITORS OF TS AND GARFT

INTRAVENOUS INJECTION

VD 16.1 LITER

PPB 81 PERCENT

Cl 5.5 LITER / HOUR

HT 3.5 HOUR

THYMIDYLATE SYNTHASE (TS)
DIHYDROFOLATE REDUCTASE (DHFR)
GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE (GARFT)

PDB 1JUJ (HUMAN THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE)

LIGAND CODE = LYA (link to the list of PDB complexes)

Download experimental 3D coordinates of LYA with added hydrogens

DIHYDROFOLATE REDUCTASE INHIBITOR CHEMBL202 DIHYDROFOLATE REDUCTASE P00374 DIHYDROFOLATE REDUCTASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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