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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PEMETREXED
| PEMETREXED | ANTIMETABOLITES | INTRAVENOUS INJECTION | VD 16.1 LITER PPB 81 PERCENT Cl 5.5 LITER / HOUR HT 3.5 HOUR | THYMIDYLATE SYNTHASE (TS) DIHYDROFOLATE REDUCTASE (DHFR) GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE (GARFT) PDB 1JUJ (HUMAN THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE) LIGAND CODE = LYA (link to the list of PDB complexes) Download experimental 3D coordinates of LYA with added hydrogens | Thymidylate synthase UNIPROT P04818 TYMS -- Dihydrofolate reductase UNIPROT P00374 DHFR more at DrugCentral | EMA | |||
