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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| IMATINIB
| IMATINIB | ANTINEOPLASTIC AGENTS | ORAL | F 98 PERCENT VD 285 LITER (EQN) PPB 95 PERCENT Cl 11 LITER / HOUR HT 18 HOUR SOLUBILITY SOLUBLE IN AQUEOUS BUFFERS < PH 5.5 BUT IS VERY SLIGHTLY SOLUBLE TO INSOLUBLE IN NEUTRAL OR ALKALINE AQUEOUS BUFFERS | BCR-ABL TYROSINE KINASE PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGF) STEM CELL FACTOR (SCF) C-KIT PDB 3MSS (ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE) LIGAND CODE = STI (link to the list of PDB complexes) Download experimental 3D coordinates of STI with added hydrogens | Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Tyrosine-protein kinase ABL1 UNIPROT P00519 ABL1 more at DrugCentral | EMA | |||
