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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IMATINIB

IMATINIB


ATC L01XE01

ANTINEOPLASTIC AGENTS
PROTEIN TYROSINE KINASE INHIBITORS
TREATMENT OF CHRONIC MYELOID LEUKEMIA (CML)

ORAL

F 98 PERCENT

VD 285 LITER (EQN)

PPB 95 PERCENT

Cl 11 LITER / HOUR

HT 18 HOUR

SOLUBILITY SOLUBLE IN AQUEOUS BUFFERS < PH 5.5 BUT IS VERY SLIGHTLY SOLUBLE TO INSOLUBLE IN NEUTRAL OR ALKALINE AQUEOUS BUFFERS

BCR-ABL TYROSINE KINASE
PLATELET-DERIVED GROWTH FACTOR RECEPTOR (PDGF)
STEM CELL FACTOR (SCF)
C-KIT

PDB 3MSS (ABL KINASE IN COMPLEX WITH IMATINIB AND FRAGMENT (FRAG2) IN THE MYRISTATE SITE)

LIGAND CODE = STI (link to the list of PDB complexes)

Download experimental 3D coordinates of STI with added hydrogens

TYROSINE-PROTEIN KINASE ABL INHIBITOR CHEMBL1862 TYROSINE-PROTEIN KINASE ABL P00519 TYROSINE-PROTEIN KINASE ABL1 HOMO SAPIENS ENZYME KINASE PROTEIN KINASE TK ABLANSM (in French)

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