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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ROSIGLITAZONE

ROSIGLITAZONE


ATC A10BG02
ATC A10BD04
ATC A10BD03

METABOLISM
THIAZOLIDINEDIONE ANTIDIABETIC AGENT
HYPOGLYCEMIC AGENTS
ANTAGONIST
TREATMENT OF TYPE 2 DIABETES

ORAL

Cmax 1.67 MICROMOLAR

F 99 PERCENT

VD 17.6 LITER

PPB 99.8 PERCENT

Cl 3.03 LITER / HOUR

HT 3.5 HOUR

SOLUBILITY SOLUBLE IN A BUFFERED AQUEOUS SOLUTION WITH PH 5 OF 2.3 BUT DECREASES WITH INCREASING PH

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONIST CHEMBL235 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA P37231 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR1 NR1C NR1C3ANSM (in French)

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