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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ROSIGLITAZONE

ROSIGLITAZONE


ATC A10BD04
ATC A10BD03
ATC A10BG02

FIBRINOLYTIC AGENTS
HYPOGLYCEMIC AGENTS
THAZOLIDINEDIONES
INSULIN SENSITIZER
VASODILATOR AGENTS
ANTIDIABETIC

ORAL

Cmax 1.67 MICROMOLAR

F 99 PERCENT

VD 17.6 LITER

PPB 99.8 PERCENT

Cl 3.03 LITER / HOUR

HT 3.5 HOUR

SOLUBILITY SOLUBLE IN A BUFFERED AQUEOUS SOLUTION WITH PH 5 OF 2.3 BUT DECREASES WITH INCREASING PH

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

PDB 1ZGY (STRUCTURAL AND BIOCHEMICAL BASIS FOR SELECTIVE REPRESSION OF THE ORPHAN NUCLEAR RECEPTOR LRH-1 BY SHP)

LIGAND CODE = BRL (link to the list of PDB complexes)

Download experimental 3D coordinates of BRL with added hydrogens

Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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