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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ABACAVIR

ABACAVIR


ATC J05AF06
ATC J05AR02
ATC J05AR13
ATC J05AR04

ANTIINFECTIVES
ANTI-HIV
ANTIVIRAL
NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

ORAL

Cmax 10.4 MICROMOLAR (300 MILLIGRAM TWICE DAILY)

F 83 PERCENT

VD 55.9 LITER (65 KILOGRAM)

PPB 50 PERCENT (INDEPENDENT OF CONCENTRATION)

Cl 52 LITER / HOUR (65 KILOGRAM)

HT 1.54 HOUR

SOLUBILITY 77 MILLIGRAM / MILLILITER (LOGP = 1.20)

GLUCURONOSYLTRANSFERASE
ALCOHOL DEHYDROGENASE
GAG-POL POLYPROTEIN

PDB 5U98 (THE CRYSTAL STRUCTURE OF A SELF-PEPTIDE COMPLEXED TO ABACAVIR AND HLA-B*57:01)

LIGAND CODE = 1KX (link to the list of PDB complexes)

Download experimental 3D coordinates of 1KX with added hydrogens

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE INHIBITOR CHEMBL247 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE Q72547 REVERSE TRANSCRIPTASE/RNASEH HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME HYDROLASEANSM (in French)

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