Cheminformatic Tools and Databases for Pharmacology

session 17744 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M SILDENAFIL (is an active metabolite)

SILDENAFIL


ATC G04BE03

GENITO
ERECTILE DYSFUNCTION (THERAPEUTIC)
SPECIFIC PHOSPHODIESTERASE INHIBITORS
VASODILATOR AGENTS
THE METABOLITE ACCOUNTS FOR ABOUT 20 PERCENT OF SILDENAFIL PHARMACOLOGIC
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH) (DRUG FOR RARE DISEASE IN EUROPE)

- PHOSPHODIESTERASE TYPE 5 (PDE5)

PHOSPHODIESTERASE 5A INHIBITOR CHEMBL1827 PHOSPHODIESTERASE 5A O76074 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_5 PDE_5AANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SILDENAFIL (has an active metabolite)

SILDENAFIL


ATC G04BE03

GENITO
ERECTILE DYSFUNCTION (THERAPEUTIC)
SPECIFIC PHOSPHODIESTERASE INHIBITORS
VASODILATOR AGENTS
TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH) (DRUG FOR RARE DISEASE IN EUROPE)

ORAL INTRAVENOUS

F 41 PERCENT

VD 105 LITER

PPB 96 PERCENT

Cl 18 LITER / HOUR (EQN)

HT 4 HOUR

SOLUBILITY 3.5 MILLIGRAM / MILLILITER

PHOSPHODIESTERASE TYPE 5 (PDE5)

PHOSPHODIESTERASE 5A INHIBITOR CHEMBL1827 PHOSPHODIESTERASE 5A O76074 CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_5 PDE_5AANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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