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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESCITALOPRAM
| ESCITALOPRAM | NERVOUS SYSTEM | ORAL | F 80 PERCENT VD 780 LITER (65 KILOGRAM) PPB 56 PERCENT Cl 36 LITER / HOUR HT 29.5 HOUR SOLUBILITY SPARINGLY SOLUBLE IN WATER | SEROTONIN TRANSPORTER PDB 5I75 (X-RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH S-CITALOPRAM AT THE CENTRAL SITE AND BR-CITALOPRAM AT THE ALLOSTERIC SITE) LIGAND CODE = 68P (link to the list of PDB complexes) Download experimental 3D coordinates of 68P with added hydrogens | Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 more at DrugCentral | EMA | |||
