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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DELAVIRDINE DISCONTINUED
| DELAVIRDINE | ANTIINFECTIVES | ORAL | Cmax 35 MICROMOLAR (400 MILLIGRAM) Tmax 1 HOUR F 85 PERCENT PPB 98 PERCENT HT 5.8 HOUR (400 MILLIGRAM) SOLUBILITY 0.81 MICROGRAM PER MILLILITER (PH=7.4) | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE (IC50=38 NANOMOLAR) GAG-POL POLYPROTEIN PDB 1KLM (HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152) LIGAND CODE = SPP (link to the list of PDB complexes) Download experimental 3D coordinates of SPP with added hydrogens | Reverse transcriptase,RNaseH UNIPROT Q72547 pol more at DrugCentral | EMA | |||
