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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PRAMIPEXOLE

PRAMIPEXOLE


ATC N04BC05

NERVOUS SYSTEM
NONERGOT DOPAMINE RECEPTOR AGONIST
RESTLESS LEGS SYNDROME (RLS)
ANTIPSYCHOTIC
ANTIPARKINSONIAN
ANTIGLAUCOMA
ANTIDYSKINETICS
DOPAMINE D2 RECEPTOR AGONIST
DOPAMINE D4 RECEPTOR AGONIST

ORAL

F 90 PERCENT

VD 500 LITER

PPB 15 PERCENT

Cl 43.3 LITER / HOUR (EQN)

HT 8 HOUR

SOLUBILITY 20 PERCENT IN WATER

D3 DOPAMINE RECEPTOR

PDB 7CMU (DOPAMINE RECEPTOR D3R-GI-PRAMIPEXOLE COMPLEX)

LIGAND CODE = G6L (link to the list of PDB complexes)

Download experimental 3D coordinates of G6L with added hydrogens

D2-LIKE DOPAMINE RECEPTOR AGONIST CHEMBL2331075 D2-LIKE DOPAMINE RECEPTOR P14416 D(2) DOPAMINE RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR DOPAMINE RECEPTORANSM (in French)

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