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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CYSTEAMINE

CYSTEAMINE


ATC A16AA04
ATC S01XA21

METABOLISM
NEPHROPATHIC CYSTINOSIS THERAPY
REACTANT
CYSTEAMINE IS AN AMINOTHIOL THAT PARTICIPATES WITHIN LYSOSOMES IN A THIOL-DISULFIDE INTERCHANGE REACTION CONVERTING CYSTINE IN TO CYSTEINE AND CYSTEINE-CYSTEAMINE MIXED DISULFIDE, BOTH OF WHICH CAN EXIT THE LYSOSOME IN PATIENTS WITH CYSTINOSIS

ORAL OPHTHALMIC

Cmax 33.7 MICROMOLAR

VD 156 LITER

PPB 52 PERCENT

Cl 72 LITER / HOUR

HT 1.5 HOUR (EQN)

SOLUBILITY HIGHLY WATER SOLUBLE

PDB 4CG4 (CRYSTAL STRUCTURE OF THE CHS-B30.2 DOMAINS OF TRIM20)

LIGAND CODE = DHL (link to the list of PDB complexes)

Download experimental 3D coordinates of DHL with added hydrogens

CYSTINE HYDROLYTIC ENZYME CHEMBL2364039 CYSTINE HOMO SAPIENSANSM (in French)

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