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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FENOLDOPAM DISCONTINUED

FENOLDOPAM


ATC C01CA19

CARDIOVASCULAR
ANTIHYPERTENSIVE
SHORT-TERM MANAGEMENT OF SEVERE HYPERTENSION
DOPAMINE AGONISTS
VASODILATOR AGENTS
BINDS MODERATLY TO ALPHA-2 ADRENERGIC RECEPTOR
R-ISOMER HAS 250-FOLD HIGHER AFFINITY THAN S-ISOMER

INJECTION

HT 0.083 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

D1 DOPAMINE RECEPTOR

PDB 7CKW (CRYO-EM STRUCTURE OF FENOLDOPAM BOUND DOPAMINE RECEPTOR DRD1-GS SIGNALING COMPLEX)

LIGAND CODE = G3C (link to the list of PDB complexes)

Download experimental 3D coordinates of G3C with added hydrogens

D(1A) dopamine receptor UNIPROT P21728 DRD1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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