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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MILRINONE

MILRINONE


ATC C01CE02

CARDIOVASCULAR
POSITIVE INOTROPE
CARDIOTONIC
PHOSPHODIESTERASE INHIBITORS
PLATELET AGGREGATION INHIBITORS
VASODILATOR AGENTS

INJECTION

VD 24.7 LITER (65 KILOGRAM)

PPB 70 PERCENT

Cl 8.4 LITER / HOUR (65 KILOGRAM)

HT 2.3 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

CAMP 3',5'-CYCLIC PHOSPHODIESTERASE 3

PDB 1TLM (STRUCTURAL ASPECTS OF INOTROPIC BIPYRIDINE BINDING: CRYSTAL STRUCTURE DETERMINATION TO 1.9 ANGSTROMS OF THE HUMAN SERUM TRANSTHYRETIN-MILRINONE COMPLEX)

LIGAND CODE = MIL (link to the list of PDB complexes)

Download experimental 3D coordinates of MIL with added hydrogens

PHOSPHODIESTERASE 3A INHIBITOR CHEMBL241 PHOSPHODIESTERASE 3A Q14432 CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE A HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_3 PDE_3AANSM (in French)

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