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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| METHYSERGIDE DISCONTINUED
| METHYSERGIDE | NERVOUS SYSTEM | ORAL | 5-HYDROXYTRYPTAMINE 1A RECEPTOR 5-HYDROXYTRYPTAMINE 2A RECEPTOR 5-HYDROXYTRYPTAMINE 2C RECEPTOR 5-HYDROXYTRYPTAMINE 7 RECEPTOR PDB 6DRZ (STRUCTURAL DETERMINANTS OF ACTIVATION AND BIASED AGONISM AT THE 5-HT2B RECEPTOR) LIGAND CODE = H8J (link to the list of PDB complexes) Download experimental 3D coordinates of H8J with added hydrogens | 5-hydroxytryptamine receptor 2B UNIPROT P41595 HTR2B -- 5-hydroxytryptamine receptor 2C UNIPROT P28335 HTR2C more at DrugCentral | EMA | ||||
