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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
GUANETHIDINE DISCONTINUED

GUANETHIDINE


ATC C02CC02
ATC S01EX01
ATC C02LF01

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC NEURON BLOCKER
SYMPATHOLYTICS

ORAL

Cmax 40 NANOMOLAR (10-50 MILLIGRAM / DAY)

HT SEVERAL DAYS

NITRIC OXIDE SYNTHASE (PMID10889350)

NOREPINEPHRINE TRANSPORTER SUBSTRATE CHEMBL222 NOREPINEPHRINE TRANSPORTER P23975 SODIUM-DEPENDENT NORADRENALINE TRANSPORTER HOMO SAPIENS TRANSPORTER ELECTROCHEMICAL SLC SLC06ANSM (in French)

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