| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PALIPERIDONE (is an active metabolite)
| PALIPERIDONE | NERVOUS SYSTEM | ORAL | Tmax 3 HOUR VD 391 LITER PPB 74 PERCENT Cl 10.8 LITER / HOUR (EQN) HT 25 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | 5-HYDROXYTRYPTAMINE 2A RECEPTOR D(2) DOPAMINE RECEPTOR ALPHA1 ADRENERGIC RECEPTOR ALPHA2 ADRENERGIC RECEPTOR H1 HISTAMINERGIC RECEPTOR PDB 8GSQ (STRUCTURE BASED STUDIES REVEAL AN ATYPICAL ANTIPSYCHOTIC DRUG CANDIDATE - PALIPERIDONE AS A POTENT HSOD1 MODULATOR WITH IMPLICATIONS IN ALS TREATMENT) LIGAND CODE = K4I (link to the list of PDB complexes) Download experimental 3D coordinates of K4I with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A more at DrugCentral | EMA | |||
