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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| LENALIDOMIDE
| LENALIDOMIDE | ANTINEOPLASTIC | ORAL | Tmax 3.25 HOUR PPB 30 PERCENT HT 3 HOUR SOLUBILITY SOLUBLE IN ORGANIC SOLVENT/WATER MIXTURES | PDB 5FQD (STRUCTURAL BASIS OF LENALIDOMIDE INDUCED CK1A DEGRADATION BY THE CRL4CRBN UBIQUITIN LIGASE) LIGAND CODE = LVY (link to the list of PDB complexes) Download experimental 3D coordinates of LVY with added hydrogens | Protein cereblon UNIPROT Q96SW2 CRBN more at DrugCentral | EMA | |||
