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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ILOPROST

ILOPROST


ATC B01AC11

BLOOD
ANTIHYPERTENSIVE
ANALOG OF PROSTACYLIN INDICATED FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION (PAH)

INHALATION

Cmax NOT DETECTABLE (PICOMOLAR)

VD 24 LITER (65 KILOGRAM)

PPB 60 PERCENT

Cl 62 LITER / HOUR (65 KILOGRAM)

HT 0.57 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN DISTILLED WATER BUFFER PH 5

PROSTACYCLIN RECEPTOR PGI2

PDB 3SP6 (STRUCTURAL BASIS FOR ILOPROST AS A DUAL PPARALPHA/DELTA AGONIST)

LIGAND CODE = IL2 (link to the list of PDB complexes)

Download experimental 3D coordinates of IL2 with added hydrogens

PROSTANOID IP RECEPTOR AGONIST CHEMBL1995 PROSTANOID IP RECEPTOR P43119 PROSTACYCLIN RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL LIPID-LIKE LIGAND RECEPTOR PROSTANOID RECEPTORANSM (in French)

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