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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DONEPEZIL
| DONEPEZIL |
NERVOUS SYSTEM | ORAL TRANSDERMAL | Cmax 160 NANOMOLAR (PMID18621671) Tmax 3 HOUR VD 910 LITER (65 KILOGRAM) PPB 96 PERCENT Cl 8.4 LITER / HOUR (65 KILOGRAM) HT 70 HOUR SOLUBILITY SOLUBLE IN WATER | ACETYLCHOLINESTERASE PDB 4EY7 (CRYSTAL STRUCTURE OF RECOMBINANT HUMAN ACETYLCHOLINESTERASE IN COMPLEX WITH DONEPEZIL) LIGAND CODE = E20 (link to the list of PDB complexes) Download experimental 3D coordinates of E20 with added hydrogens | Acetylcholinesterase UNIPROT P22303 ACHE more at DrugCentral | EMA | |||
