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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FELODIPINE

FELODIPINE


ATC C08CA02
ATC C07FB02
ATC C09BB05

CARDIOVASCULAR
VASODILATOR
ANTIHYPERTENSIVE
ANTI-ARRHYTHMIA AGENTS
CALCIUM CHANNEL BLOCKERS
DIHYDROPYRIDINES
S ENANTIOMER MORE ACTIVE

ORAL

Cmax 2 NANOMOLAR

Tmax 4.5 HOUR

F 20 PERCENT

VD 650 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 48 LITER / HOUR

HT 14 HOUR

SOLUBILITY INSOLUBLE IN WATER

VOLTAGE-DEPENDENT CALCIUM L-CHANNEL

PDB 2NNJ (CYP2C8DH COMPLEXED WITH FELODIPINE)

LIGAND CODE = 225 (link to the list of PDB complexes)

Download experimental 3D coordinates of 225 with added hydrogens

VOLTAGE-GATED L-TYPE CALCIUM CHANNEL BLOCKER CHEMBL2095229 VOLTAGE-GATED L-TYPE CALCIUM CHANNEL O60840 VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F HOMO SAPIENS ION CHANNEL VGC VG CAANSM (in French)

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