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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
EVEROLIMUS

EVEROLIMUS


ATC L04AA18
ATC L01XE10

ANTINEOPLASTIC
INHIBITOR OF SERINE-THREONINE KINASE MTOR (MAMMALIAN TARGET OF RAPAMYCIN) DOWNSTREAM OF THE PI3K/AKT PATHWAY BY BINDING TO FKBP-12
ADVANCED PANCREATIC NEUROENDOCRINE TUMORS
IMMUNOSUPPRESSANT
PROPHYLAXIS OF ORGAN REJECTION
TREATMENT OF RENAL ANGIOMYOLIPOMA ASSOCIATED WITH TUBEROUS SCLEROSIS COMPLEX AND TREATMENT OF SUBEPENDYMAL GIANT CELL ASTROCYTOMA ASSOCIATED WITH TUBEROUS SCLEROSIS COMPLEX (DRUG FOR RARE DISEASE IN EUROPE)

ORAL

VD 358 LITER

PPB 74 PERCENT

Cl 8.2 LITER / HOUR (EQN)

HT 30 HOUR

SOLUBILITY POORLY SOLUBLE IN WATER

FK506 BINDING PROTEIN-12 (FKBP-12)/MTOR COMPLEX

FK506-BINDING PROTEIN 1A INHIBITOR CHEMBL1902 FK506-BINDING PROTEIN 1A P62942 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A HOMO SAPIENS ENZYME ISOMERASEANSM (in French)

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