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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| MEXILETINE
| MEXILETINE | CARDIOVASCULAR | ORAL | F 90 PERCENT VD 360 LITER PPB 55 PERCENT Cl 30 LITER / HOUR HT 11 HOUR SOLUBILITY FREELY SOLUBLE IN WATER | SODIUM CHANNEL PDB 2VIN (FRAGMENT-BASED DISCOVERY OF MEXILETINE DERIVATIVES AS ORALLY BIOAVAILABLE INHIBITORS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR) LIGAND CODE = 505 (link to the list of PDB complexes) Download experimental 3D coordinates of 505 with added hydrogens | Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A -- Sodium channel protein type 2 subunit alpha UNIPROT Q99250 SCN2A more at DrugCentral | EMA | |||
