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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
FLURBIPROFEN

FLURBIPROFEN


ATC M01AE09
ATC M02AA19
ATC R02AX01
ATC S01BC04

MUSCULO-SKELETAL SYSTEM
ANALGESICS
NSAID
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL
CYCLOOXYGENASE INHIBITORS

ORAL OPHTHALMIC

Cmax 57 MICROMOLAR

Tmax 2 HOUR

F 96 PERCENT

VD 7.8 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 1.08 LITER / HOUR (EQN)

HT 5 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB 3RR3 (STRUCTURE OF (R)-FLURBIPROFEN BOUND TO MCOX-2)

LIGAND CODE = FLR (link to the list of PDB complexes)

Download experimental 3D coordinates of FLR with added hydrogens

CYCLOOXYGENASE INHIBITOR CHEMBL2094253 CYCLOOXYGENASE P23219 PROSTAGLANDIN G/H SYNTHASE 1 HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

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