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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DIPIVEFRIN DISCONTINUED (has an active metabolite)

DIPIVEFRIN


ATC S01EA02

SENSORY
ADRENERGIC AGONISTS
SYMPATHOMIMETICS
CONTROL OF INTRAOCULAR PRESSURE IN CHRONIC OPEN-ANGLE GLAUCOMA

OPHTHALMIC

SOLUBILITY FREELY SOLUBLE IN WATER

ALPHA-2A ADRENERGIC RECEPTOR

Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A -- Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B -- Alpha-2C adrenergic receptor UNIPROT P18825 ADRA2C

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
EPINEPHRINE (is an active metabolite)

EPINEPHRINENATURAL MOLECULE (link)


ATC A01AD01
ATC B02BC09
ATC C01CA24
ATC R01AA14
ATC R03AA01
ATC S01EA01
ATC R03AK01
ATC S01EA51

METABOLISM
ADRENERGIC AGONISTS
BRONCHODILATOR AGENTS
MYDRIATICS
SYMPATHOMIMETICS
VASOCONSTRICTOR AGENTS
EMERGENCY TREATMENT OF SEVERE ALLERGIC REACTIONS

INJECTION INHALATION INTRAMUSCULAR SUBCUTANEOUS IONTOPHORESIS TOPICAL INTRAVENOUS INTRAOCULAR

HT 0.05 HOUR

SOLUBILITY SOLUBLE IN WATER

ALPHA ADRENERGIC RECEPTOR
BETA ADRENERGIC RECEPTOR

PDB 4LDO (STRUCTURE OF BETA2 ADRENOCEPTOR BOUND TO ADRENALINE AND AN ENGINEERED NANOBODY)

LIGAND CODE = ALE (link to the list of PDB complexes)

Download experimental 3D coordinates of ALE with added hydrogens

Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 -- Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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