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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AMINOGLUTETHIMIDE DISCONTINUED

AMINOGLUTETHIMIDE


ATC L02BG01

ANTINEOPLASTIC
AROMATASE INHIBITORS
INHIBITOR OF ADRENOCORTICAL STEROID SYNTHESIS
ANTICONVULSANT (WITHDRAWN)
SUPPRESSION OF ADRENAL FUNCTION IN SELECTED PATIENTS WITH CUSHINGÂ’S SYNDROME

ORAL

Cmax 25.4 MICROMOLAR

Tmax 1.5 HOUR

F 100 PERCENT

HT 12.5 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER

CYTOCHROME P450

CYTOCHROME P450 11A1 INHIBITOR CHEMBL2033 CYTOCHROME P450 11A1 P05108 CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL HOMO SAPIENS ENZYME CYTOCHROME P450 CYP_11 CYP_11A CYP_11A1ANSM (in French)

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