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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DOBUTAMINE
| DOBUTAMINE | CARDIOVASCULAR | INJECTION | Cmax 332 NANOMOLAR VD 13 LITER Cl 249 LITER / HOUR HT 0.033 HOUR | BETA-1 ADRENERGIC RECEPTOR CATECHOL O-METHYLTRANSFERASE (COMT) PDB 2Y00 (TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)) LIGAND CODE = Y00 (link to the list of PDB complexes) Download experimental 3D coordinates of Y00 with added hydrogens | Beta-1 adrenergic receptor UNIPROT P08588 ADRB1 -- Beta-2 adrenergic receptor UNIPROT P07550 ADRB2 more at DrugCentral | EMA | |||
