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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HYDRALAZINE
| HYDRALAZINE | CARDIOVASCULAR | ORAL INJECTION | Cmax 583 NANOMOLAR (PMID24702251) Tmax 2.5 HOUR F 18 PERCENT VD 143 LITER (65 KILOGRAM) PPB 88 PERCENT Cl 331.5 LITER / HOUR (65 KILOGRAM) HT 1 HOUR SOLUBILITY SOLUBLE IN WATER | PDB 3LTW (THE STRUCTURE OF MYCOBACTERIUM MARINUM ARYLAMINE N-ACETYLTRANSFERASE IN COMPLEX WITH HYDRALAZINE) LIGAND CODE = HLZ (link to the list of PDB complexes) Download experimental 3D coordinates of HLZ with added hydrogens | Ryanodine receptor 2 UNIPROT Q92736 RYR2 more at DrugCentral | EMA | |||
