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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HYDROCORTISONE (is an active metabolite)
| HYDROCORTISONE |
DERMATOLOGICALS | ORAL TOPICAL VAGINAL INJECTION OTIC RECTAL OPHTHALMIC | VD 24.7 LITER (65 KILOGRAM) PPB 80 PERCENT Cl 22.2 LITER / HOUR (65 KILOGRAM) HT 1.6 HOUR | GLUCOCORTICOID RECEPTOR PDB 2VDY (CRYSTAL STRUCTURE OF THE REACTIVE LOOP CLEAVED CORTICOSTEROID BINDING GLOBULIN COMPLEXED WITH CORTISOL) LIGAND CODE = HCY (link to the list of PDB complexes) Download experimental 3D coordinates of HCY with added hydrogens | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| HYDROCORTISONE BUTYRATE (has an active metabolite)
| HYDROCORTISONE BUTYRATE | DERMATOLOGICALS | TOPICAL | SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | GLUCOCORTICOID RECEPTOR | Glucocorticoid receptor UNIPROT P04150 NR3C1 more at DrugCentral | EMA | |||
