Cheminformatic Tools and Databases for Pharmacology

session 35828 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE (is an active metabolite)

HYDROCORTISONE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

DERMATOLOGICALS
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
ADRENAL INSUFFICIENCY (DRUG FOR RARE DISEASE IN EUROPE)

ORAL TOPICAL VAGINAL INJECTION OTIC RECTAL OPHTHALMIC

VD 24.7 LITER (65 KILOGRAM)

PPB 80 PERCENT

Cl 22.2 LITER / HOUR (65 KILOGRAM)

HT 1.6 HOUR

GLUCOCORTICOID RECEPTOR

PDB 2VDY (CRYSTAL STRUCTURE OF THE REACTIVE LOOP CLEAVED CORTICOSTEROID BINDING GLOBULIN COMPLEXED WITH CORTISOL)

LIGAND CODE = HCY (link to the list of PDB complexes)

Download experimental 3D coordinates of HCY with added hydrogens

GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE VALERATE (has an active metabolite)

HYDROCORTISONE VALERATE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

DERMATOLOGICALS
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
RAPIDLY HYDROLYZED IN HYDROCORTISONE

TOPICAL

SOLUBILITY INSOLUBLE IN WATER

GLUCOCORTICOID RECEPTOR

GLUCOCORTICOID RECEPTOR AGONIST CHEMBL2034 GLUCOCORTICOID RECEPTOR P04150 GLUCOCORTICOID RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C1ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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