Cheminformatic Tools and Databases for Pharmacology

session 86553 - Total of 7 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTAMATE DISCONTINUED (has an active metabolite)

HYDROCORTAMATE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

DERMATOLOGICALS
GLUCOCORTICOID
ANTI-INFLAMMATORY
CORTICOSTEROID
IMMUNOSUPPRESSIVE AGENTS

TOPICAL GLUCOCORTICOID RECEPTOR

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE (is an active metabolite)

HYDROCORTISONE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

DERMATOLOGICALS
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
ADRENAL INSUFFICIENCY (DRUG FOR RARE DISEASE IN EUROPE)

ORAL TOPICAL VAGINAL INJECTION OTIC RECTAL OPHTHALMIC

VD 24.7 LITER (65 KILOGRAM)

PPB 80 PERCENT

Cl 22.2 LITER / HOUR (65 KILOGRAM)

HT 1.6 HOUR

GLUCOCORTICOID RECEPTOR

PDB 2VDY (CRYSTAL STRUCTURE OF THE REACTIVE LOOP CLEAVED CORTICOSTEROID BINDING GLOBULIN COMPLEXED WITH CORTISOL)

LIGAND CODE = HCY (link to the list of PDB complexes)

Download experimental 3D coordinates of HCY with added hydrogens

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

3 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE ACETATE (has an active metabolite)

HYDROCORTISONE ACETATE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

DERMATOLOGICALS
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
RAPIDLY HYDROLYZED IN HYDROCORTISONE

TOPICAL INJECTION OPHTHALMIC OTIC RECTAL GLUCOCORTICOID RECEPTOR

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

4 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE BUTYRATE (has an active metabolite)

HYDROCORTISONE BUTYRATE


ATC D07AB02
ATC D07BB04

DERMATOLOGICALS
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
RAPIDLY HYDROLYZED IN HYDROCORTISONE

TOPICAL

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

GLUCOCORTICOID RECEPTOR

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

5 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE CYPIONATE DISCONTINUED (has an active metabolite)

HYDROCORTISONE CYPIONATE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

METABOLISM
GLUCOCORTICOID
AGONIST
ANTI-INFLAMMATORY

ORAL GLUCOCORTICOID RECEPTOR

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

6 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE PROBUTATE (has an active metabolite)

HYDROCORTISONE PROBUTATE


ATC D07AB11

DERMATOLOGICALS
AGONIST
GLUCOCORTICOID
ANTI-INFLAMMATORY

TOPICAL GLUCOCORTICOID RECEPTOR

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

7 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
HYDROCORTISONE VALERATE (has an active metabolite)

HYDROCORTISONE VALERATE


ATC A01AC03
ATC A07EA02
ATC C05AA01
ATC D07AA02
ATC D07XA01
ATC H02AB09
ATC S01BA02
ATC S01CB03
ATC S02BA01
ATC D07AC16
ATC D07CA01
ATC S01CA03
ATC S02CA03
ATC S03CA04
ATC D07BA04
ATC S01BB01
ATC D07AB11
ATC D07AB02
ATC D07BB04
ATC R01AD60

DERMATOLOGICALS
GLUCOCORTICOID
ANTIINFLAMMATORY
VASOCONSTRICTOR
RAPIDLY HYDROLYZED IN HYDROCORTISONE

TOPICAL

SOLUBILITY INSOLUBLE IN WATER

GLUCOCORTICOID RECEPTOR

Glucocorticoid receptor UNIPROT P04150 NR3C1

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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