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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DRONEDARONE

DRONEDARONE


ATC C01BD07

CARDIOVASCULAR
ANTIARRHYTHMIC
MULTI-CHANNEL BLOCKER THAT AFFECTS CALCIUM, POTASSIUM AND SODIUM CHANNELS

ORAL

F 15 PERCENT

VD 1400 LITER

PPB 98 PERCENT

Cl 140 LITER / HOUR

HT 16 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

IONIC CHANNELS

POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1 O60741 POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1 HOMO SAPIENS ION CHANNEL VGC C-GMPANSM (in French)

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