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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
AZACITIDINE

AZACITIDINE


ATC L01BC07

ANTINEOPLASTIC
ANTIMETABOLITES
FAB MYELODYSPLASTIC SYNDROME
CYTOTOXIC
NUCLEOSIDE ANALOG OF CYTIDINE
HYPOMETHYLATION OF DNA AND RNA AFTER PHOSPHORYLATION BY KINASE UCK2

INTRAVENOUS SUBCUTANEOUS ORAL

Cmax 3 MICROMOLAR

F 89 PERCENT

VD 76 LITER

Cl 167 LITER / HOUR

HT 0.68 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

URIDINE-CYTIDINE KINASE 2 (UCK2)

PDB 4QD3 (CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH 5-AZACYTIDINE AT 1.89 ANGSTROM RESOLUTION)

LIGAND CODE = 5AE (link to the list of PDB complexes)

Download experimental 3D coordinates of 5AE with added hydrogens

DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 INHIBITOR CHEMBL1993 DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 P26358 DNA (CYTOSINE-5)-METHYLTRANSFERASE 1 HOMO SAPIENS EPIGENETIC REGULATOR WRITER DNMTANSM (in French)

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