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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IVERMECTIN

IVERMECTIN


ATC D11AX22
ATC P02CF01

ANTIPARASITIC
ANTHELMINTICS
ANTINEMATODAL AGENTS
ANTIPROTOZOAL AGENTS
INCREASE THE PERMEABILITY OF THE CELL MEMBRANE TO CHLORIDE IONS WITH HYPERPOLARIZATION BUT DOES NOT READILY CROSS THE BLOOD-BRAIN BARRIER IN HUMANS
BINDS GLYCINE RECEPTOR

ORAL TOPICAL

Cmax 53 NANOMOLAR

Tmax 4 HOUR

PPB 99 PERCENT

HT 18 HOUR

SOLUBILITY INSOLUBLE IN WATER

GLYCINE RECEPTOR (GLYR)
GLUTAMATE-GATED CHLORIDE CHANNEL
GABA RECEPTOR
NS3 HELICASE (PMID22535622)

PDB 3JAF (DANIO RERIO ALPHA-1 GLYCINE RECEPTOR BY CRYO-EM)

LIGAND CODE = IVM (link to the list of PDB complexes)

Download experimental 3D coordinates of IVM with added hydrogens

Glutamate-gated chloride channel UNIPROT P91730 -- Glutamate-gated chloride channel UNIPROT Q25634 GluClX

more at DrugCentral

EMA

ANSM (in French)

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Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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