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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IVERMECTIN

IVERMECTIN


ATC P02CF01
ATC D11AX22

ANTIPARASITIC
ANTHELMINTICS
ANTINEMATODAL AGENTS
ANTIPROTOZOAL AGENTS
INCREASE THE PERMEABILITY OF THE CELL MEMBRANE TO CHLORIDE IONS WITH HYPERPOLARIZATION BUT DOES NOT READILY CROSS THE BLOOD-BRAIN BARRIER IN HUMANS
BINDS GLYCINE RECEPTOR

ORAL TOPICAL

Cmax 53 NANOMOLAR

Tmax 4 HOUR

PPB 99 PERCENT

HT 18 HOUR

SOLUBILITY INSOLUBLE IN WATER

GLYCINE RECEPTOR (GLYR)
GLUTAMATE-GATED CHLORIDE CHANNEL
GABA RECEPTOR
NS3 HELICASE (PMID22535622)

PDB 3JAF (DANIO RERIO ALPHA-1 GLYCINE RECEPTOR BY CRYO-EM)

LIGAND CODE = IVM (link to the list of PDB complexes)

Download experimental 3D coordinates of IVM with added hydrogens

GLUTAMATE-GATED CHLORIDE CHANNEL MODULATOR CHEMBL2363050 GLUTAMATE-GATED CHLORIDE CHANNEL P91730 GLUTAMATE-GATED CHLORIDE CHANNEL SUBUNIT BETA STRONGYLOIDES STERCORALIS ION CHANNEL LGICANSM (in French)

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