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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TACROLIMUS

TACROLIMUS


ATC D11AX14
ATC D11AH01
ATC L04AD02

IMMUNOMODULATING AGENT
IMMUNOSUPPRESSIVE
PHOSPHATASE ACTIVITY OF CALCINEURIN INHIBITED
PROTEIN-PROTEIN INHIBITOR (PPI)
PROPHYLAXIS OF ORGAN REJECTION
MACROLIDE

ORAL INJECTION TOPICAL

Cmax 36.9 NANOMOLAR

F 18 PERCENT

VD 126.1 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 2.6 LITER / HOUR (65 KILOGRAM)

HT 34.8 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

FKBP-12

PDB 3O5R (COMPLEX OF FK506 WITH THE FK1 DOMAIN MUTANT A19T OF FKBP51)

LIGAND CODE = FK5 (link to the list of PDB complexes)

Download experimental 3D coordinates of FK5 with added hydrogens

FK506-BINDING PROTEIN 1A INHIBITOR CHEMBL1902 FK506-BINDING PROTEIN 1A P62942 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A HOMO SAPIENS ENZYME ISOMERASEANSM (in French)

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