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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
MEROPENEM

MEROPENEM


ATC J01DH02
ATC J01DH52

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CARBAPENEMS
PENICILLIN-BINDING PROTEIN INHIBITOR

INJECTION INTRAVENOUS

Cmax 127.9 MICROMOLAR

VD 19.5 LITER (65 KILOGRAM)

PPB 2 PERCENT

Cl 15.2 LITER / HOUR (65 KILOGRAM)

HT 1 HOUR

SOLUBILITY SPARINGLY SOLUBLE IN WATER

PENICILLIN-BINDING PROTEIN (PBP)

PDB 4EUZ (CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1 S70A-MEROPENEM COMPLEX)

LIGAND CODE = MEM (link to the list of PDB complexes)

Download experimental 3D coordinates of MEM with added hydrogens

BACTERIAL PENICILLIN-BINDING PROTEIN INHIBITOR CHEMBL2354204 BACTERIAL PENICILLIN-BINDING PROTEIN P02918 PENICILLIN-BINDING PROTEIN 1A BACTERIA ENZYME PROTEASE SERINE UNCLASSIFIEDANSM (in French)

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