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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RIFABUTIN
| RIFABUTIN | ANTIINFECTIVES | ORAL | Cmax 443.2 NANOMOLAR F 20 PERCENT VD 604.5 LITER (65 KILOGRAM) PPB 85 PERCENT Cl 44.8 LITER / HOUR HT 45 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER (0.19 MILLIGRAM / MILLILITER) | DNA-DIRECTED RNA POLYMERASE PDB 4CP3 (THE STRUCTURE OF BCL6 BTB (POZ) DOMAIN IN COMPLEX WITH THE ANSAMYCIN ANTIBIOTIC RIFABUTIN.) LIGAND CODE = RBT (link to the list of PDB complexes) Download experimental 3D coordinates of RBT with added hydrogens | Bacterial DNA-directed RNA polymerase UNIPROT P0A7Z4 rpoA more at DrugCentral | EMA | |||
