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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RIFABUTIN

RIFABUTIN


ATC J04AB04

ANTIINFECTIVES
TUBERCULOSTATIC
ANTIFUNGAL
ANTIBIOTIC
ANTIBACTERIAL
DNA-DEPENDENT RNA POLYMERASE INHIBITOR

ORAL

Cmax 443.2 NANOMOLAR

F 20 PERCENT

VD 604.5 LITER (65 KILOGRAM)

PPB 85 PERCENT

Cl 44.8 LITER / HOUR

HT 45 HOUR

SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER (0.19 MILLIGRAM / MILLILITER)

DNA-DIRECTED RNA POLYMERASE

PDB 4CP3 (THE STRUCTURE OF BCL6 BTB (POZ) DOMAIN IN COMPLEX WITH THE ANSAMYCIN ANTIBIOTIC RIFABUTIN.)

LIGAND CODE = RBT (link to the list of PDB complexes)

Download experimental 3D coordinates of RBT with added hydrogens

BACTERIAL DNA-DIRECTED RNA POLYMERASE INHIBITOR CHEMBL2364672 BACTERIAL DNA-DIRECTED RNA POLYMERASE P0A8T7 DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' BACTERIA ENZYME TRANSFERASEANSM (in French)

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