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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TAZOBACTAM

TAZOBACTAM


ATC J01CG02

ANTIINFECTIVES
BETA-LACTAMASE INHIBITOR

INJECTION INTRAVENOUS

Cmax 113.3 MICROMOLAR

Tmax 1 HOUR

VD 18.2 LITER

PPB 30 PERCENT

Cl 12.3 LITER / HOUR

HT 1.2 HOUR

PENICILLIN-BINDING PROTEIN

PDB 1VM1 (STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM)

LIGAND CODE = TAZ (link to the list of PDB complexes)

Download experimental 3D coordinates of TAZ with added hydrogens

BACTERIAL BETA-LACTAMASE TEM INHIBITOR CHEMBL2364670 BACTERIAL BETA-LACTAMASE TEM P62593 BETA-LACTAMASE TEM BACTERIA ENZYME HYDROLASEANSM (in French)

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